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When carcinoma begins to metastasize, it enters into blood vessel or lymphatic vessel to migrate to the site of metastasis. In that case, although I think breaking down the basement membrane is necessary for epithelium such as carcinoma to enter into them, I can't find out the reports. Are the basement membrane actually broken down in the first step of metastasis?What are the molecular mechanisms in which carcinoma enters into blood or lymphatic vessels?

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    $\begingroup$ You can read about epithelial to mesenchymal transition. It is one of the processes that usually precedes metastasis of carcinomas. $\endgroup$ – WYSIWYG Aug 24 '16 at 8:46
  • $\begingroup$ Thanks for answering my question, I have already known that the EMT system is one of ways of metastasis. However what i want to know is whether carcinoma actually breaks down the basement membrane when it stats to metastasize. Do you know some reports showing histochemically the broken down basement membrane? $\endgroup$ – ironKUMA Aug 25 '16 at 4:32
  • $\begingroup$ @ironKUMA The linked Wikipedia article has many citations to the primary literature, I would suggest starting there. You should also perform some appropriately-worded Google Scholar and PubMed searches for more information. $\endgroup$ – MattDMo Aug 26 '16 at 17:58

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