Can Pichia pastoris (species of yeast used for recombinant protein) produce the non-protein amino acid Ornithine? Or does it express ornithine at all?

  • $\begingroup$ is the pichia pastoris genome available from some sequence database? you could search for ornithine synthetic genes $\endgroup$ – Vance L Albaugh Aug 30 '16 at 18:44
  • $\begingroup$ yes, i can look for the pichia pastoris genome sequence on NCBI. do you suggest that i compare the genome sequence of pichia and ornithine and see if there is a match between them ? $\endgroup$ – Fiona Aug 30 '16 at 19:07

Yes, it contains arginase. Thise enzyme converts arginine to ornithine and is probably part of the urea cycle.

You might notice the arginase is listed as coming from Komagataella phaffii GS115, but this is just another (new?) name for Pichia.


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