I have read many articles on bacteriophages (like the lambda phage1) being used for transferring genes into mammalian cells, but none of them mention any sort of lysis of the cells even though in bacteria, lysis would occur. Of course, killing the cell would beat the purpose of the gene transfer, but why doesn't the bacteriophage kill the mammalian cells? Has there been any research on lysis of the mammalian cells with phages?

  • $\begingroup$ Lambda phage undergoes lysogenic cycle where host cell is not lysed immediately, it becomes a prophage and divides along the host cell. It causes lysis when exposed to UV or some other chemicals. $\endgroup$ – JM97 Sep 2 '16 at 2:46
  • $\begingroup$ @JM97 are there any bacteriophages that do lyse immediately? $\endgroup$ – TanMath Sep 5 '16 at 23:23

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