So the title I chose might be a bit too broad or even misleading compared to the specific example I have in mind, but I couldn't choose something longer or more specific than that, so I apologize if that's the case!
Due to its close connection to Autism Spectrum Disorders (ASD) and even some personality dimensions in psychology and my interest in these topics, I was reading an article about the reward circuit (cortico-basal ganglia reward network: microcircuitry, Susan R Sesack and Anthony A. Grace, 2010) which in my opinion is a pretty nice article and as the title suggests talks about the different parts of the cortico-basal ganglia network mostly at a fairly high level of detail (e.g. nucleus accumbens, ventral tegmental area, prefrontal cortex, etc), their interconnections, some physical characteristics of those interconnections, the associated neurotransmitters for the different parts and connections, and some of the functional implications of these topics, and also presents a couple of nice diagrams depicting the afferents and efferents of this circuit. as far as I understand and perhaps obviously, most of this data comes from primate and mouse data, however I would imagine there could be a lot of similarity in humans, and we also approximately know from cognitive neuroscience or other disciplines the general function of some (if not most) parts of this circuit.
The question that came to my mind is, which area of neuroscience or biology deals with modeling and simulating this circuit at this level (not necessarily at the neuron to neuron level) to understand it better, and also understand the effects that genetics or environment could have on it, so that ultimately we might for example come up with a treatment for ASD? is it more related to systems neuroscience, computational neuroscience, systems biology, or even bioinformatics and computational genomics?
Thanks in advance!