Meiotic drive is a type of intragenomic conflict, whereby one or more loci within a genome will affect a manipulation of the meiotic process in such a way as to favor the transmission of one or more alleles over another, regardless of its phenotypic expression. More simply, meiotic drive is when one copy of a gene is passed on to offspring more than the expected 50% of the time.

But do humans have such genes?


Yes! Jeffrey and Neumann 2002 report evidence of meiotic drive at a recombination hot spot in the MHC.

Note that mtDNA could arguably be considered as an extreme case of sex-dependent meiotic drive. Mothers transmit mtDNA at rate of almost 1, while fathers transmit mtDNA at a rate of almost 0.


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