I have a protein that is produced with the baculovirus system that is recognized by antibodies generated by immunization of rabbits with the same protein produced in E. coli. However the baculovirus protein did not induce an antibody response when I immunized some pigs.
Could it be that the baculovirus protein is not immunogenic? Even if the same protein is recognized by antibodies? If the rabbits produced antibodies with a protein that did not have post-translational modifications, how can not be immunogenic when the modifications are added?