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In sexually transmitted infections, it is important to differentiate a painful ulcer from a painless one. This is because painless ulcers are seen in the chancre of primary syphilis while painful tender ones are seen in Herpes and though rare, in chancroid (H. ducreyi).

I can guess that it must be due to peripheral nerves, but how does this happen?

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    $\begingroup$ My hat's off to you. Not only have I never wondered about this, but having consulted Cecil's, Harrison's, several neurology texts, and other scholarly sources, not a single source addresses this. $\endgroup$ – anongoodnurse Oct 26 '16 at 23:39
  • $\begingroup$ It is small things like these that we generally ignore.. Thanks :') @anongoodnurse $\endgroup$ – Polisetty Oct 27 '16 at 0:08

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