I have a dim recollection of having heard that when humans gain weight, adipose cells just get larger, rather than dividing. True?

  • $\begingroup$ The Wikipedia entry for Adipocyte has a whole section on cell turnover. "If excess weight is gained as an adult, fat cells increase in size about fourfold before dividing and increasing the absolute number of fat cells present." citation $\endgroup$ – QuietThud Nov 21 '12 at 6:34
  • 1
    $\begingroup$ @QuietThud please consider fleshing out your comment a little and posting it as an answer. $\endgroup$ – terdon Nov 21 '12 at 14:02

My foray into the literature suggests that mature adipocytes do not divide. See, for example:

Lefterova, MI et al. (2009) New developments in adipogenesis. Trends in Endocrinology and Metabolism 20:107-114

In the context of looking at the possibility of stimulating the conversion of white adipose tissue to brown adipose tissue, the authors outline the way in which the expansion of adipose tissue occurs by a process in which fibroblast-like pre-adipocytes differentiate into cells capable of storing lipid droplets and responding to insulin.

It appears therefore that expansion of adipose tissue occurs by the generation of new adipocytes. Thinking of the morphology of a fully-loaded adipocyte (a lipid droplet surrounded by a narrow band of cytoplasm) it seems rather unlikely that these cells would be capable of division. The Wikipedia citation linked to by QuietThud in the comments to the OP is to a popular book on nutrition, not an authoritative source.


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.