I want to get a list of FDA-approved drugs with unknown mechanism of action. I think that there should be a database where for each drug there is a short field "mechanism", but I haven't find one. Do you know any database where I can find such information? Another possible way is to use text-mining programs to analyze scientific libraries like PubMed and find the drugs which names often occur together with words "mechanism" and "unknown". Are there any good programs which can do it? Any other suggestions are welcome too, of course.

  • $\begingroup$ Are there any drug "approved" in medical-science (not-about the alternative medicines); whose working principle we do not know? at least partly? $\endgroup$ Nov 21, 2016 at 14:13
  • 1
    $\begingroup$ There are a lot! Most drugs bind many targets, and nobody knows for sure which targets are responsible for the drug action. For example, look at wide-used drug modafinil (drugbank.ca/drugs/DB00745) $\endgroup$
    – khorms
    Nov 22, 2016 at 0:24


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