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Are they found in humans? I'm wondering because they display a structural similarity to glucose-6-phosphatase, which is an important enzyme in gluconeogenesis.

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  • $\begingroup$ Could you add some details of the structural similarity - from a quick search, I see that chloroperoxidases has a 3-layer sandwich (alpha-beta hydrolase) fold and G6P has a number of subunits. $\endgroup$ – gilleain Nov 21 '16 at 18:15
  • $\begingroup$ I can look for more on that but my primary question is what organisms they are found in. $\endgroup$ – jovialplutonium Nov 21 '16 at 20:33
  • $\begingroup$ A good start is to look for the EC in RCSB : rcsb.org/pdb/results/… there's an 'organism' box on the left hand side $\endgroup$ – gilleain Nov 21 '16 at 22:52
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It is only found in an ascomycetes which is named Leptoxyphium fumago, also known as Caldariomyces fumago.

It isn't found in any other specie that we know of yet as searched on the RCSB PDB and Uni-Prot.

In researches that uses it they extract it from the organism, it is also available to buy from companies like Sigma Aldrich who extract it from the ascomycete too.

Sources:

Improvement of activity and stability of chloroperoxidase by chemical modification

Over-expression of chloroperoxidase in Caldariomyces fumago.

RCSB Protein Data Bank

Uni-Prot

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