I wanted to know, if it is possible to prove a new organism as an animal model for any human disease by only Bioinformatics methods like NGS and Structural bioinformatics.
For Example, let's say Drosophila is an animal model for Disease X as it have some 60-70% similarity in the gene and protein structure. Can we prove, a newer organism is a better model for X, if it shows a higher similarity, let's say 80-85%, to gene and protein structure of human?
UPDATE (First I posted it as comment! But I think, this is suited here best!)
@David: Thanks for your answer! Actually, I did looked into it, Large animal models of rare genetic disorders: sheep as phenotypically relevant models of human genetic disease. I am more interested in listing down the problems if we do start this kind of project in our lab. Do NGS is a solution or what part of biology we need to focus so, that we can be more accurate.