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From Berg's Biochemistry:

Most newly synthesized RNA chains carry a highly distinctive tag on the 5′ end: the first base at that end is either pppG or pppA.

Is there a reason why the synthesis initiates with a purine?

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  • $\begingroup$ From this paper, which is the 2nd result of a Google search for rna synthesis begin with purine, the abstract ends with this sentence: "Our results suggest that the purine-rich sequences at the 5' ends of the nascent transcripts of many genes act to stabilize the early ternary complex." You can read the papers citing this one to learn more if you wish. $\endgroup$ – MattDMo Dec 21 '16 at 0:27
  • $\begingroup$ I didn't find any suitable result with the keywords I was using. Anyways thank you. @MattDMo $\endgroup$ – Tyto alba Dec 21 '16 at 8:57
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Purine-rich sequences at the 5' ends of the nascent transcripts of many genes act to stabilize the early ternary(elongation) complex.

P.S.Source: MattDMo's comment.

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