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In the scholarpedia page on interneurons I encountered the following passage:

The perisomatic domain is responsible for the summation of postsynaptic potentials arriving from all dendritic branches [...]. Thus, the perisomatic region - and particularly the axon initial segment [...] plays a crucial role in the generation of output.

The page, however, does not define what the perisomatic region really is. What comprises the perisomatic region of an interneuron?

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  • $\begingroup$ Sure mate. If these edits are not to your liking feel free to roll it back. It's just that in the linked Scholarpedia page the term is not explained anywhere. Quoting the relevant section shows that to other users nicely. $\endgroup$ – AliceD Jan 5 '17 at 11:24
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In cortical GABAergic cells with local axonal projections, the perisomatic region is defined as that part of the plasma membrane including the proximal dendrites, the cell body and the axon initial segment (Zabó et al., 2010).

Reference
- Zabó et al., Eur J Neurosci (2010); 31(12): 2234–46

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    $\begingroup$ Now that I read your answer, maybe I should have deduced it from the name.. However I didn't so... Thank you! $\endgroup$ – user135172 Jan 5 '17 at 11:22
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    $\begingroup$ @user135172 - No worries and happy to help - I had to look it up too. Nice question and well researched +1 $\endgroup$ – AliceD Jan 5 '17 at 11:22
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'Peri' = 'in the region of'

'soma' = 'cell body'

so the perisomatic region is the area in the region of the cell body - I thought the breakdown might be useful in future as 'peri' is used a lot.

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