I'm new to using Kegg and not sure how to interpret the position of the pathway enzymes in the pathway that I'm looking at. More specifically: If all boxes (of KOs) must be present/colored green or not for a reaction to occur.
I'm looking at this pathway: http://www.kegg.jp/kegg-bin/show_pathway?ooe00010
Looking at the 'help' for Kegg indicates that the KOs represent a protein complex, because the boxes are 'stacked' against each other. Is this correct?
Specific reactions that I've been looking at: alpha-D-glucose-6P to beta-D-glucose-6P (One box is there, the other is missing). Or the route from Glyceraldehyde-3P to pyruvate. I'm thinking that these pathways must be present, but in the very first reaction only 1 of 2 boxes are colored. I suppose it's also a possibility that Kegg's database is simply incomplete?