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is it possible at least theoretically to change the DNA of an organism ?

so we take for example an organism with multiple cells then we change its DNA without killing this organism

to correct genetic defects or to improve it

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    $\begingroup$ See this. $\endgroup$
    – Tyto alba
    Jan 11, 2017 at 13:29
  • $\begingroup$ Yes, it is possible, but you have to engineer the totipotent stem cell that forms all the other cells in the organism's body. There is no way to alter the DNA of every single cell in a human or mouse, for example, after they have begun developing. $\endgroup$
    – MattDMo
    Jan 11, 2017 at 21:19

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Erm. Sort of. Kind of depends on your definition. It hasn't been done for multicellular organisms though.

Craig Venter et al did this exact experiment a few years ago with a completely synthetic Mycoplasma genome.

http://www.jcvi.org/cms/press/press-releases/full-text/article/first-minimal-synthetic-bacterial-cell-designed-and-constructed-by-scientists-at-venter-institute-an/

If you just want to change small segments of DNA that's where cloning and gene therapy come in, and we do that A LOT.

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