In prokaryotes, GroEL protein (together with GroES) is required for protein folding.
Question: Can a bacterium survive without GroEL protein?
Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. It only takes a minute to sign up.Sign up to join this community
There doesn't appear to be a knockout for it in the Keio collection (they systematically knocked out genes in E coli to assess essentiality, via recombineering).
If they couldn't knock it out, that strongly suggests it's an essential gene and the organism cannot survive without it.