Monoclonal gammopathy of unknown significance (MGUS) is often considered a pre-cancerous condition.

Blood donors with MGUS are typically advised to discontinue blood donation as their blood may be risky for blood recipients.

This paradigm has been recently challenged (e.g. La Raia 2015), but also reinforced (e.g. Felldin 2016).

It is also possible that blood donation may be risky for donors with MGUS as well, as it leads to an overall boost and stimulation in hematopoiesis which may indirectly favor prograssion from MGUS to myeloma.

Is it true?

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    $\begingroup$ People in the UK are prohibited from donating with MGUS. $\endgroup$ – Rod Jan 22 at 19:28

Here are the facts and I want to be clear here! According to the US Veterans Administration and I have MGUS with the Bense Jones proteins so I know this to be true. According to the VA having MGUS and then eventually developing Multiple Myeloma are mutually exclusive. You should be able to and allowed to donate blood, plasma, organs, and even bone marrow. I have been trying for years to get the VA recognize my condition as service connected even though it occurred while I was on active duty even though I had some of the symptoms while on active duty - the VA has continued to refuse to recognize my condition. So... based upon this - please feel free to become a donor or resume making donations and do so with the VA's blessing!

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    $\begingroup$ Welcome to Biology.SE. A good answer should be backed up with references, not with a I have MGUS with the Bense Jones proteins so I know this to be true. When you say According to the US [VA], you could just add a link to their policy for example. I have been trying for years [..] While I can't help but to feel sorry for you struggling with US VA, I must highlight that personal experience of the kind are very irrelevant to the question and does not has its place on a biology forum. Good luck! $\endgroup$ – Remi.b Jan 24 at 7:13

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