I'm a physicist writing a proposal that has to do with cancer as a disease driven by evolutionary selection. As far as I understand, all tumors start with a single precursor (single cell or group of cells), and the other cells derive from this precursor by cycles of alterations and selection processes.
Reading recent articles, such as this, I learned that the derived cells include both
subclones. Since I'm not sure I understood things correctly, I have a few questions on the difference between the two words:
- Is it OK to call
clonesthe cells derived from the precursors?
- When should I use
- In the case of heterogeneity, is it fine to call
clonal populationa group of clones with the same characteristics?