How long ago did DNA start to include sequences that code for protein?


closed as too broad by David, AliceD, kmm, fileunderwater, James Feb 2 '17 at 3:56

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    $\begingroup$ where have you looked for information on this? online, google, wikipedia? $\endgroup$ – Vance L Albaugh Jan 29 '17 at 18:50
  • $\begingroup$ Protein isn't synthesised from DNA it's synthesized from RNA. $\endgroup$ – David Jan 29 '17 at 19:11
  • $\begingroup$ I've googled it first yes, I could not find it. And yes, I realize that protein get synthesized from RNA, but the protein is coded in the DNA. My question is, when did DNA code start to contain information on the proteins that are the result of gene expression. Sorry if my formulation caused confusion. $\endgroup$ – Abdel Feb 1 '17 at 18:59

There are two questions being asked here.

1) When DNA was used to encode RNA via DNA dependent RNA polymerase It is uncertain if the Last Universal Common Ancestor (LUCA) had this enzyme. There is some debate.

Also some DNA polymerases of family A, B are structurally related to RNA polymerases https://www.ncbi.nlm.nih.gov/books/NBK6360/. So DNA may have come after RNA. The switch to DNA has been proposed to be a result from a reaction to the evolution of RNAse.

2) When RNA was used to encode protein via ribosome LUCA has ribosome. So LUCA had proteins made from RNA https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926754/

And LUCA has been estimated to have appear around 3.5-3.8 billion years ago. https://en.wikipedia.org/wiki/Last_universal_common_ancestor

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    $\begingroup$ Please define the abbreviation LUCA in your answer. $\endgroup$ – David Jan 29 '17 at 19:12
  • $\begingroup$ Last Universal Common Ancestor. $\endgroup$ – JayCkat Jan 30 '17 at 15:40
  • $\begingroup$ I worked that out, but I shouldn't have to. Define it in your answer so that everyone knows. The use of undefined acronyms is lazy and inconsiderate and decreases the value of an answer. $\endgroup$ – David Jan 30 '17 at 17:44
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    $\begingroup$ DNA and RNA... which actually stand for Deoxyribose Nucleic Acid and Ribose Nucleic Acid. $\endgroup$ – JayCkat Jan 30 '17 at 22:19
  • $\begingroup$ I am afraid that this will not wash. More people know what DNA and RNA are than know what it stands for. As you are not willing to clarify your answer, then I shall your do it for you, although I hardly think it worth it for such a poor question. Also the last common ancestor hasn't been around since 3.5-3.8 billion years ago — that would imply it is still around. It was thought to have lived then. $\endgroup$ – David Jan 31 '17 at 0:26

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