Antibodies and Hepatitis viruses both have hypervariable regions. Is one more adaptable than the other? Precisely how adaptable are they? I have read that antibodies can be trained to bind to almost any antigen, is the same true for Hepatitis?
Long-Term Evolution of the Hypervariable Region of Hepatitis C Virus in a Common-Source-Infected Cohort https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110045/
I guess the first step to answering this is to find/conduct a study in which the Hepatitus virus is mutated and selected for a particular antigen. I am not sure if this has been done, but it definately has been done for antibodies.