I was recently at a Leukemia and Lymphoma Society conference where a particular oncologist lecturer claimed that all antibodies are created in the bone marrow (I won't mention his name, as he was a great lecturer, and I don't wish to sully his name if he happened to be wrong on this particular point).
Wikipedia seems to indicate that antigens are produced in "Secondary Lymphatic Organs" or occasionally in the bone marrow, but I've been misled by Wikipedia before. It seems to me that evolution would favor creating antibodies close to the infection, and not far away in the bone marrow or lymphatic organs (how would the antibodies "know" how to get back to the original infection? It would be very inefficient to send antibodies all over the body if the infection is localized.)
My questions is: Could someone "map out" the travel of a typical B-cell throughout the body from the time the B-cell detects an antigen up to the time it produces antibodies (and if it later stops producing anti-bodies, please include that)?