Why adrenal medulla can not utilise fatty acids for generation of energy? What could be the benefit for not having ability to use fatty acids?

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  • $\begingroup$ Does it have something to do with feedback mechanism? $\endgroup$
    – JM97
    Feb 10, 2017 at 7:34
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    $\begingroup$ Interesting question. Do you have a reference showing that fatty acids cannot be used? The adrenal medulla is basically a specialized nervous tissue, and neurons are usually considered to be unable to oxidize fatty acids, but other cell types in the CNS do oxidize fatty acids, see for example hindawi.com/journals/bmri/2014/472459 $\endgroup$
    – Roland
    Feb 10, 2017 at 17:26
  • $\begingroup$ but the blood brain barrier is not present in adrenal medulla. $\endgroup$
    – JM97
    Feb 10, 2017 at 23:24
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    $\begingroup$ I was hoping for a reference to actual experimental data, rather than just somebody else claiming the same thing. I did find some textbooks that repeat this statement (without reference), so perhaps it's valid, but textbooks can also be inaccurate ... Also, the blood-brain barrier does allow fatty acid transport (contrary to statements in some textbooks :), see for example ncbi.nlm.nih.gov/pubmed/17901540 See also my related question biology.stackexchange.com/questions/34159/… $\endgroup$
    – Roland
    Feb 11, 2017 at 10:22
  • $\begingroup$ Also, we should consider the possibility that there is no benefit. Some features of biology are not good for the organism, but evolution just hasn't come up with any better solution. $\endgroup$
    – Roland
    Feb 11, 2017 at 10:24


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