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Hardy Weinberg would predict that the frequency of normal females, to carrier females, to affected females for colorblindness is equal to p$^2$ + 2pq + q$^2$=1. You were told that q=freq of the recessive allele. If p+q =1 (frequency of the dominant allele + frequency of the recessive allele=1 or 100%) and q=.08, what is the frequency of the normal allele in the population? What is the frequency of carrier females in the population (ie heterozygous females)?

I get that the frequency of the normal allele is p = 1 - .08 so 0.92. However the frequency of carrier females is giving me an unrealistic number. Using p$^2$ + 2pq + q$^2$ =1, the value for pq comes out to be a negative value. Is it safe to just multiply p and q since that is what we're essentially solving for using the full HW equation? This would make the value (.08*.92) = 0.0736. Would that be the way to approach the problem even though it asks for females only?

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closed as off-topic by Remi.b, another 'Homo sapien', Bryan Krause, James, kmm Feb 28 '17 at 2:16

This question appears to be off-topic. The users who voted to close gave this specific reason:

  • "Homework questions are off-topic on Biology unless you have shown your attempt at an answer. For more information see our homework policy." – Remi.b, another 'Homo sapien', Bryan Krause, James, kmm
If this question can be reworded to fit the rules in the help center, please edit the question.

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    $\begingroup$ Welcome to Biology.SE. Homework questions are off-topic on Biology unless you have shown your attempt at an answer. For more information see our homework policy. $\endgroup$ – Remi.b Feb 12 '17 at 22:03
  • $\begingroup$ Btw, although the question is quite clear, the phrasing is a bit inaccurate and misleading. Is it the question as written for your homework? $\endgroup$ – Remi.b Feb 12 '17 at 22:33
  • $\begingroup$ Yes, that is the exact wording of the problem! $\endgroup$ – Swetha Feb 12 '17 at 23:05
  • $\begingroup$ check your math, the value for pq comes out to be a negative value is incorrect $\endgroup$ – Oct18 is day of silence on SE Feb 12 '17 at 23:23
  • $\begingroup$ Thank you, got the value to be .0736. Would this be correct as to being the frequency of carrier females? $\endgroup$ – Swetha Feb 12 '17 at 23:31
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Carrier females= 2pq= 2 x .08 x 0.92

Because carriers say with genotype Aa (A=dominant, a=recessive) can arise due to two types of inheritances;one when A is from father and a is from mother and the other when it is just opposite.

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