I know what viruses are. They replicate only inside the living cells, and so on, and so on.

I just interesting maybe there is some progress in this field. I don't know exactly, but I suppose before invention of the nutrient agar microorganisms were cultivated on substrates like eggs, potatoes, meat etc. Perhaps there is the same story for viruses.

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    $\begingroup$ No. A virus is a small infectious agent that replicates only inside the living cells of other organisms. -Wikipedia $\endgroup$ – Tyto alba Feb 19 '17 at 19:34
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    $\begingroup$ +1'd and it doesn't seem like a homework question. It seems the OP want to tell they knows virus doesn't grow if not in living cell- but if there is any latter-discovery of any virus-like particle growing outside living cell. $\endgroup$ – Always Confused Feb 20 '17 at 16:41
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    $\begingroup$ I agree with @AlwaysConfused - I see no reason to close or put this question on hold, it does not seem like a homework question, especially after the OP's recent edits I would suggest the hold be removed. $\endgroup$ – Bryan Krause Feb 21 '17 at 20:05
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    $\begingroup$ Voted to reopen. I was reading a paper from the 30's which claimed to cultivate Vaccinia in the absence of living cells. However a later paper admitted that they couldn't be sure there were no living cells in the media. Of course, given what we now know, contamination with life cells seems most likely. $\endgroup$ – canadianer Feb 22 '17 at 0:46
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    $\begingroup$ It depends. Some viruses (like Vaccinia used above) are highly complex and would need a cell to be synthesized (with today's tech). If you take simple viruses, say Poliovirus, you could make the RNA and that alone could be infectious if placed in a cell. This isn't a true virus though, more of a viroid. That being said, take PCV, the single protein will self-assemble and incorporate vDNA, while it might not have been done, this could be theoretically be made in vitro. $\endgroup$ – Artem Feb 22 '17 at 0:49

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