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The other day, my teacher suggested we find out whether a chain of the following amino acid sequence would be able to form a coiled-coil:

N-KIAEVRAQYEDVANKVRLIVE-C

Now, I can see that the chain is not amphiphilic as it does not alternate between polar and non polar amino acids. But when I come across an exercise of this type, how do I determine if it can actually form coiled coils? I can feel this will be a question on the final test. All help is deeply appreciated.

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  • $\begingroup$ onlinelibrary.wiley.com/doi/10.1002/cbic.200300781/full $\endgroup$ – canadianer Feb 27 '17 at 21:23
  • $\begingroup$ Thank you so much!! I still have the same question. In every article I read, it says: A and G positions are typically hydrophobic. Why typically? Can positions that are not A and G be hydrophobic and still make up a coiled coil? $\endgroup$ – Bee Feb 27 '17 at 22:08
  • $\begingroup$ I don't know, but I expect that exceptions to the rule can be tolerated. You should ask your instructor what they are expecting from you. $\endgroup$ – canadianer Feb 27 '17 at 22:15
  • $\begingroup$ Okay, thank you anyway for trying to help me. I, too, think that exceptions can be tolerated just by looking at alpha-keratin sequences that have so many exceptions and yet they form coiled coils! But it is hard to translate to simple cases as the one I proposed above. Thanks again! $\endgroup$ – Bee Feb 27 '17 at 22:18

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