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I want to get a score using Rosetta for how well a protein binds to a ligand. I understand RosettaDock has a score called I_sc which will give me a number to indicate that.

I found documentation in https://www.rosettacommons.org/demos/latest/tutorials/scoring/scoring about how Rosetta scores structures, but not sure what scoring function RosettaDock uses and whether it is the talaris2014 score.

So the question is what scoring function is used in RosettaDock for calculating I_sc.

Cheers

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Unless you (a) ran some absolutely ancient version of Rosetta or (b) explicitly specified a different score function, your protocol should have used the current default ref2015. This will be the default until a few years when the next major update is released.

You can verify this by checking your log file, which should have a line like core.scoring.ScoreFunctionFactory: SCOREFUNCTION: ref2015

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