The popular MuTect variant tool:


has the following VCF option:

--cosmic < comic.vcf >

Q: What is this cosmic VCF file? What's the purpose of the file?


VCF is an abbreviation for Variant Call Format. It is a file format for SNPs.

COSMIC stands for Catalogue Of Somatic Mutations In Cancer. It is a database.

Have a look at the links for more information.

A COSMIC VCF is likely just a file in VCF format file containing data coming from the COSMIC data base.


Without looking at any mutect docs and how it might use this, the COSMIC VCF would refer to a VCF from the cosmic database http://cancer.sanger.ac.uk/cosmic/


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.