I was wondering, when we have an amino acid sequence, is it enough to check whether the positions a-d correspond to hydrophobic amino acids in order to say whether it can form a coiled coil structure? Or would we need to make sure the other positions are not hydrophobic too?

All help greatly appreciated.


1 Answer 1


The heptad repeat, denoted [abcdefg]n, typically has hydrophobic residues at a and d, and polar/charged residues at e and g.

From here.

There is a prediction tool with useful images here.


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