In Ménière's disease, an ednolymphatic hydrops (EH) in scala media leads to a distention and, eventually, rupture of Reissner's membrane. This results in an influx of K+-rich endolymph into the Na+-rich perilymph of scala vestibuli.

Supposedly, this causes an "injury to the sensory and neural elements of the inner ear, which manifests clinically as sudden hearing loss, tinnitus, and vertigo."

What is the pathophysiological mechanism? Aren't these elements part of the Organ of Corti, not in the perilymphatic space?

  • $\begingroup$ It would be nice if you could cite your sources for most of your information. This appeals to the community that you have done your research. $\endgroup$ – Imtiaz Raqib May 27 '17 at 16:29
  • $\begingroup$ source: my ENT textbook and BMJ $\endgroup$ – Sai May 27 '17 at 17:35
  • $\begingroup$ It would be better to mention it in your question itself with links that can guide the community to the sources so they can read more if needed. See Here on how to link your sources. $\endgroup$ – Imtiaz Raqib May 27 '17 at 17:39

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