Is there any database that contain binding affinities reported in litterature for different proteins and ligands?

I have checked uniprot already and it does not seem to included any binding affinity data, for several well characterised receptors such as the human insulin receptor.

  • 1
    $\begingroup$ You could try this or this. I haven't used either, but searching for a protein that I work with gave disappointing results. $\endgroup$ – canadianer May 30 '17 at 3:08
  • $\begingroup$ Brenda has a LOT of values from literature than can indicate binding (KI, IC50, Km), but only for enzymes not for proteins in general. $\endgroup$ – Nicolai May 30 '17 at 4:43
  • $\begingroup$ @canadianer I think it just gives binding of (pharmacological) small molecules to proteins. I just searched stat1 to see if it gives the binding energy of stat1 with its receptors. It doesn't. It rather considers stat1 as a target and returns two small molecules. So, I guess there is no good database for binding affinities. $\endgroup$ – WYSIWYG Jan 14 '19 at 14:22

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.