In paper Mutational heterogeneity in cancer and the search for new cancer-associated genes, Figure 1 defines:

Somatic mutation frequencies observed in exomes from 3,083 tumour–normal pairs. Each dot corresponds to a tumour–normal pair, with vertical position indicating the total frequency of somatic mutations in the exome.

Is the figure representing with each point a tumor/normal pair because somatic mutations (differently from germline mutations) are assumed to not be present in the normal sample?


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.