I know that type 1 diabetics do not produce enough (possibly none) insulin since beta cells of pancreas are damaged and as far as I know glucagon is produced by alpha cells (which are healthy in diabetic body, I suppose). So, my question is that since glucagon is released when the blood glucose is low, why do the diabetics experience hypoglycemia? Shouldn't the glucagon be released and increase the blood sugar?
Note that in Role of Alpha Cells in Diabetes1, the following is stated:
Glucagon responses to hypoglycemia have been known to be blunted in type 1 diabetes of long duration, and this may be a result of a loss of alpha- and beta-cell communication secondary to insulin deficiency.
- Rudy W Bilous. Role of Alpha Cells in Diabetes - Medscape - Apr 11, 2003.