I'm very new in biology and doing more computational analysis. I'm confused with the type of interactions between Transcription Factors (TF) and target genes.
Is it possible that the same transcription factor interacts differently with the same target gene under different conditions?
e.g., TF1
up-regulates Gene1
under condition 1
while TF1
down-regulates the same gene Gene1
under condition 2
Does the above example take place in biological systems?
I can only think of different TF complexes which are regulating the gene Gene1
under different conditions with different effect. However, it would be great to know if, in case TF1
does not participate in any TF complexes to regulate Gene1
under certain conditions, it is then possible that "TF1" regulates Gene1
differently under different conditions?