It is a well-known fact that both of these cells can reach the lymphatic vessels from interstitial space. How does it do so physically? Are there any mathematical models describing this process? It seems like there are endothelial cells along the lymphatic vessels that act like valves, so I would assume that these "valves" open, the cancer cells/WBCs would fit through to reach the lumen?
This question is also a reference request. I am looking for papers that describes the process of intravasation of WBCs and cancer cells into the lymphatic capillaries? Mathematical models are preferable but this is such a niche topic that probably there are no mathematical models.