I know that there is existing research on ultrasound-induced transient cavitation bubbles that mechanically denature DNA by generating violent shock waves locally in solution.

I would like to know if it is possible for non-cavitating ultrasound to denature short strands of DNA, ~20 base pairs in length (please cite sources, if possible). The mechanism should be mechanical, without involving thermal or cavitation effects of ultrasound. The ultrasound acts as a pressure wave, of the order of 10 MPa, and the DNA helices require a force of ~15 pN to initiate unzipping. I just need proof that this has been successfully demonstrated.

Thank you in advance.

  • $\begingroup$ Does DNA denature? $\endgroup$ – 4D Neuron Aug 14 '17 at 15:24

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