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Is exposure to the chemical O4I2 (ethyl 2-((4-chlorophenyl)amino)-thiazole-4-carboxylate) sufficient to reprogram an adult cell back to pluripotency?
They sell this chemical online for pretty cheap. My question is, if I wanted to start a colony of induced pluripotent stem (iPS) cells, would I only need to buy this or are other reprogramming materials required?
No, the chemical O4I2 (thats a name, not a chemical formula btw) only helps to induce production of the Oct-4 transcription factor. Even if just this chemical is sufficient to express Oct-4 (which it might not be, I'm not really sure about that), you still need to induce transcription of other genes (usually Sox, cMyc & Klf4) to obtain iPS cells.
