Because most of this research is over a decade old, finding a paper with a figure that clearly shows that (neuronal) synaptic plasticity (such as long-term potentiation/LTP) is NMDA receptor mediated has proven very difficult for me.

Is there a good reference for this?

  • $\begingroup$ Not all types of LTP are NMDA-receptor mediated. To find a paper that shows a form that is, I would suggest searching terms like LTP and NMDA antagonist or blockade or similar. $\endgroup$ – Bryan Krause Sep 13 '17 at 22:36

One of the "Boss references" (nearly 11000 citations right now) for this is Bliss and Collingridge, A Synaptic Model of Memory: Long-Term Potentiation in the Hippocampus. Being from 1993, it has references to some of the earlier work in this field (if that's what you're looking for). It notes the different forms of NMDA-dependent and independent plasticity. Another paper, also from 1993, on this topic is Malenka and Nicoll, NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

Some nice reviews with more recent work, focusing on the NMDAR itself include:

  • Paoletti et al, NMDA Receptor Subunit Diversity: Impact on Receptor Properties, Synaptic Plasticity and Disease
  • Lau & Zukin, NMDA Receptor Trafficking in Synaptic Plasticity and Neuropsychiatric Disorders

and their references.

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  • $\begingroup$ would you directly recommend a figure out of these papers? $\endgroup$ – user2305193 Sep 18 '17 at 15:19
  • $\begingroup$ @user2305193 What exactly are you hoping for the figure to show? $\endgroup$ – user3658307 Sep 18 '17 at 15:57
  • $\begingroup$ the NMDA receptor dependency within LTP $\endgroup$ – user2305193 Sep 18 '17 at 18:23
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    $\begingroup$ @user2305193 How about Malenka and Nicoll's figure 1 (which is actually taken from one of their references)? That shows its dependency experimentally. If you're talking about conceptually, maybe box 2 in Bliss and Collingridge? $\endgroup$ – user3658307 Sep 18 '17 at 18:52

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