LTP was first described by Tim Bliss and Terje Lømo in their paper Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.

When was LTD first described? By whom?


1 Answer 1


The process of long-term depression (LTD) was first discovered in the cerebellum by Ito et al. in 1982:

Ito M, Kano M. Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex. Neurosci Lett. 1982;33(3):253-8

Ito M, Sakurai M and Tongroach P. Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. Journal of Physiology 1982; 324: 113–134.

Check this source.


You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .