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Red blood cells do not have a considerable number of MHC1 through their membranes, and that's explained by them not having a nucleus. But why do platelets have MHC1s if they have no nucleus either? I don't think that lifespan is a good enough explanation since that would mean young red blood cells have MHC1s and old platelets don't, since the latter can last over a week in circulation. Megakaryocytes do have MHC1s, but that means nothing, since red blood cell percursors also have them.

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    $\begingroup$ There's actually a good answer to this on Quora. $\endgroup$ – CKM Oct 13 '17 at 17:38

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