1
$\begingroup$

Can CRISPR-Cas9 make changes on a living organism? What's the limit here? E.g. reversing/restoring hearing loss in a living adult mice.

$\endgroup$
  • $\begingroup$ Hearing loss is a particularly tricky phenotype to mention, because a) hearing loss has many many, sometimes unrelated, causes, and b) because hearing loss is often associated with death of cells that do not reproduce in adults. $\endgroup$ – Bryan Krause Jun 1 '18 at 17:48
1
$\begingroup$

Answer is yes, but it depends on which kind of phenotype you're going to restore/change. As you can imagine, using crispr cas9 on an high amount of cells require one condition: edited cells need to have a clear advantage in surviving besides the previous.

Here's an example of a crispr-cas9 protocol followed to restore a wildtype phenotype in adult mice.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.