I am confused. I know that a DNA molecule is made of two polynucleotides.

But does each polynucleotide represent one nucleic acid? If so, a DNA molecule is made of two nucleic acids, right?

Or do the two polynucleotides (that form a molecule of DNA) make up only one nucleic acid? If so, a DNA molecule is only made of one nucleic acid, right?

  • $\begingroup$ What do you mean by "two polynucleotides"? I would say "two polynucleotide strands" - start with a nucleotide, connect some of them together and you have a nucleic acid (strand), join two of those and you get double-stranded DNA. Is this not covered in wikipedia pages like : en.wikipedia.org/wiki/Nucleic_acid ? $\endgroup$ – gilleain Nov 14 '17 at 13:08
  • $\begingroup$ Well, each strand of a DNA molecule makes up one polynucleotide... Right? $\endgroup$ – Mark Nov 14 '17 at 13:18
  • $\begingroup$ I would just say it "is" a polynucleotide, but yes - double stranded DNA is two polynucleotide strands wrapped into a helix. $\endgroup$ – gilleain Nov 14 '17 at 13:40
  • $\begingroup$ See that's the problem... You're talking about "polynucleotide strands". But how many polynucleotides is there in one strand of DNA: a) one b) many? $\endgroup$ – Mark Nov 14 '17 at 14:02
  • $\begingroup$ One. A polynucleotide is made of multiple nucleotides - it is a strand. $\endgroup$ – gilleain Nov 14 '17 at 14:14

There are two types of nucleic acids: 1) DNA --> which is double-stranded, so it's made of only two polynucleotides 2) RNA --> which is single-stranded so it's made of only one polynucleotide. So if we get back to my original question "Is a single polynucleotide necessarily and always a nucleic acid?" --> the answer is no, for DNA is a nucleic acid and it is made of two polynucleotides.

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    $\begingroup$ Wrong. Some viruses have single-stranded DNA (ssDNA). One polynucleotide = one DNA molecule (always). Two polynucleotides = two DNA molecules (always). (Note: two strands of DNA are two molecules; two strands in double-stranded DNA are still two molecules, because there is no covalent bond between them. $\endgroup$ – user37894 Nov 14 '17 at 16:43
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    $\begingroup$ ...and some RNA viruses are double-stranded. As I commented previously, I suggest you stop counting the strands in nucleic acids and study their biology. $\endgroup$ – David Nov 14 '17 at 22:34

Your question arrangement is wrong, DNA is made up of 2 polynucleotide strand indeed. And these polynucleotides are the polymers of nucleotides, where nucleotides consist of deoxyribose sugar in case of DNA and ribose sugar in case of RNA+nitrogenous base+phosphate. Yes it is always a nucleic acid.


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