So, I've been researching cellular respiration on my own, and trying to keep track of most of the major processes. However, I do have one question left: I can't seem to find any sort of information about how Coenzyme A (I think it's made in the cytosol) is transferred to the matrix (the inside of the mitochondria, inside the inner membrane). Is it transported with a shuttle like for NAD+/NADH, a translocase like for ATP/ADP, or something else? Thank you for your time.
Zhyvoloup et al. (2003) J Biol Chem 278: 50316-50321; emphasis mine:
CoA synthase is localized on the mitochondrial outer membrane. Moreover, we demonstrate for the first time that phosphatidylcholine and phosphatidylethanolamine, which are the main components of the mitochondrial outer membrane, are potent activators of both enzymatic activities of CoA synthase in vitro. Taken together, these data provide the evidence that the final stages of CoA biosynthesis take place on mitochondria and the activity of CoA synthase is regulated by phospholipids.