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Let us suppose two cells A and B communicating with one another, I want to know how do cells ensure time synchronization while communicating. For instance, let us assume cell A sends a sequence '110'. Where '1' corresponds to dissemination of certain number of molecules, while '0' corresponds to no transmission of molecules. Now, cell B detects first '1', and then because of some delay in the reception of another '1', the sequence now received is '101'. I want to know that how do cells ensure time synchronization?

Or because of very small distances over communication range, there is no need of it?

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    $\begingroup$ As far as I know, cells don't detect sequences like you're proposing (though of course, there could be exceptions). While cells can detect changes in signal over time, it's not as straightforward as on/off, and this is generally modeled in analog terms via complex sets of differential equations. $\endgroup$ – AJK Dec 20 '17 at 18:06
  • $\begingroup$ Look at, e.g. science.sciencemag.org/content/298/5596/1241 for some examples of how cells can respond to transient signals of different lengths $\endgroup$ – AJK Dec 20 '17 at 18:08
  • $\begingroup$ Maybe the more robust option for sending signals like "111" vs "110" is combinatorial regulation - multiple different types of molecules, so information is conveyed by seeing whether molecule X is high AND molecule Y is high, etc. $\endgroup$ – AJK Dec 20 '17 at 18:12
  • $\begingroup$ Sorry! But I can't understand your last comment, do you want to say that some type of AND gate is used here to doubly ensure the proper detection. $\endgroup$ – Userhanu Dec 21 '17 at 9:23

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