-1
$\begingroup$

Is it possible for an immune system to exist that makes antibodies but does not possess any kind of immunological memory? If so, what examples are there?

$\endgroup$
  • $\begingroup$ have you tried googling this? $\endgroup$ – Oct18 is day of silence on SE Jan 3 '18 at 0:26
  • $\begingroup$ @aaaaaa yes, but I couldn't find the answer of my question. $\endgroup$ – differntial Jan 3 '18 at 1:02
  • 1
    $\begingroup$ Disagree with the close votes. This may not be a particularly sophisticated question but it's certainly within the scope of biology. $\endgroup$ – iayork Jan 3 '18 at 14:40
2
$\begingroup$

There is no system that makes antibodies but that doesn't have memory.

The title of this question is was originally very different from the body. The title asks if there's "any immune system without immunological memory", while the body asks if there's "any immune system that makes antibodies but has not immunological memory". That suggests you may think that antibodies are an essential part of an immune system, or that immune systems comprise only antibodies. Neither is true. The vast majority of animals have immune systems that do not have antibodies and that do not have immunological memory; for example, arthropods, the various kinds of worms, etc.

Immunological memory is a relatively recent addition to the immune system, having arisen approximately 400 million years ago, in the lineage that originated with shark-like fish. The species that evolved from sharks -- fish, amphibians, reptiles, birds, mammals -- all have immunological memory, and all have antibodies. Those species that didn't arise from that lineage do not have antibodies, and with two exceptions do not have immunological memory.

The exceptions are lampreys and hagfish, which have a common ancestor with sharks but which ended up forming an immune system that is related to, but often quite different from, that of sharks (and us). Lampreys and hagfish have molecules that are not antibodies but that function in a similar way, including having a form of immunological memory, though it's quite different from ours. So if you're looking for an example of something that kind of has antibodies but that kind of doesn't have immunological memory, that's as close as you're going to get.

Note that virtually all species, including mammals, have branches of the immune system that don't have immunological memory. Those branches don't have antibodies, though.

$\endgroup$
  • 1
    $\begingroup$ I’m not sure I agree with your characterisation of immunological memory as recent. I couldn’t find its evolutionary age with a cursory search but for all I know CRISPR (an immunological memory) could well be ancient. Similar for other cell-based immune mechanisms that rely on integration of foreign genetic material. $\endgroup$ – Konrad Rudolph Jan 3 '18 at 14:59
  • $\begingroup$ I don't really accept that CRISPR is "immunological memory" other than in semantics. $\endgroup$ – iayork Jan 3 '18 at 15:45
  • $\begingroup$ Huh. How is it not? $\endgroup$ – Konrad Rudolph Jan 3 '18 at 15:56
  • 1
    $\begingroup$ I’m not playing semantics games. But we do seem to have different definitions. That's what semantics means. Really, I don't want to make a big deal of this. What I'm saying is that bacterial "immunity" is so utterly different from animal immunity that there's virtually no biological insights to be gained from grouping them together. The dictionary certainly lets you do that, but there's no biological utility to it. It's like asking if a virus is alive. It tells you about the word "alive" but nothing about viruses. It's not (biologically) interesting. $\endgroup$ – iayork Jan 3 '18 at 16:20
  • 1
    $\begingroup$ Well “games” suggests that I’m baiting you but I’m not — rather, I simply don’t understand you. Your last comment clarified that somewhat although now I could complain about eukaryotic chauvinism (but I shan’t!). $\endgroup$ – Konrad Rudolph Jan 3 '18 at 16:23

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.