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While reading into visual phototransduction I was surprised to learn that photoreceptor cells are actually depolarized when there is NO excitation (no light, i.e. when you see nothing, black) and hyperpolarized when there is light (I expected the opposite).

This got me thinking...

Let the collection of neurons located within the eye be referred-to as IEN (inside-eye neurons) and, similarly, the collection of neurons directly linked to the eye, yet external to it be referred-to as OEN (outside-eye neurons).

Let the collection of neurons directly getting input from the retina be referred-to as RN (retinal neurons). I'm assuming RN < IEN (subset of - correct me if I'm meaningfully-wrong).

And finally, let the collection of neurons that directly link to OENs but are part of IEN be referred-to as XN (eXporter-neurons, in the sense that they export visual information from the eye to the "listeners" outside of it).

So the path of visual stimulus would then be RN -> [...] -> XN -> OEN.

Now, if my eyes were to be completely popped-out I'm assuming that relative to OENs that would have the same effect as XNs not passing along any excitatory/inhibitory information at all. Also, since what I'd perceive would be pure black, that seems to imply that XNs also don't get activated at all when we actually see black (e.g. close our eyes in a very dark room).

So, when we perceive black => RNs get depolarized => they release glutamate continuously => XNs don't excite/inhibit OENs at all (seems to also imply that RNs don't intersect XNs). It is this inversion that intrigues me - why is it that for XNs to transmit NO information RNs have to continuously be excited? By that sense, this makes me think of the eye as if it was a big NOT gate.

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Short answer
The reason for the depolarized state of photoreceptors in the dark is unknown as far as I know. It probably has its roots deep in the evolution of the eye.

Background
Indeed, photoreceptors are continuously active in the dark. A steady current flows through open channels (mainly Na+ ions). This current is called the dark current and it partially depolarizes the photoreceptor cell. The depolarized photoreceptor releases neurotransmitter (glutamate) to secondary neurons. Upon illumination of the photoreceptors rhodopsin molecules are isomerized to the active form and the photoreceptor cascade (Fig. 1) is initiated. This ultimately closes the cation channels in the photoreceptor's membrane, stopping the dark current. This leads to cell membrane hyperpolarization and inhibition of glutamate release to the second-order neuron (Fig. 1).

Admittedly, I do not know why phototransduction exactly is organized this way. There is a lot known about the evolutin of phototransduction (e.g., Lamb et al., 2016), but why the dark current exists is unknown as far as I know. I surmise it is probably an evolutionary relic. Evolution eventually has to work with pre-exisiting features to generate new structures, or alter them. Simple photosensitive spots evolved into the complex eyes observed in today's vertebrates. Evolution thereby used what was there and that happened to be an energetically unfavorable 'NOT' gate.

Phototransduction
Fig. 1. Phototransduction in photoreceptors. source: Kolb, (2012)

Reference
- Kolb, Webvision. The Organization of the Retina and Visual System (2012)
- Lamb et al., Molec Biol Evol (2016); 33(8): 2064–87

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    $\begingroup$ Thank you very much for your detailed answer. As I was reading it, another possible explanation struck me that might make the NOT gate behaviour actually energetically favourable: with a NOT gate it's always one or the other (primary/secondary neurons) consuming energy - the alternative would make both consume energy at the same time when there's light. So maybe a NOT gate makes it possible overall to consume less energy. $\endgroup$ – Corneliu Zuzu Jan 3 '18 at 11:25
  • $\begingroup$ And yet another idea: even if the overall energy consumption is slightly larger with the NOT gate behaviour, there might actually be another trick evolution has played - energy consumption is still smaller in the case when there is light - but unlike darkness, light also means substantial visual content to process. In short, it might matter more to consume less energy in light (to "redirect" the rest to the secondary neurons processing the visual content) than consuming none in darkness. $\endgroup$ – Corneliu Zuzu Jan 3 '18 at 12:46

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