9
$\begingroup$

Inspired by this question among others.

It's widely suggested that the current 3-base codon system of encoding protein sequences in DNA evolved from an earlier 2-base codon system. This makes sense if you look at the coding sequences themselves but I fail to understand how it can evolve? Wouldn't any shift wreck the coding of all existing proteins?

Perhaps they could overlap, but wouldn't even that produce nonsense and how would it shift to non-overlapping codons? Perhaps both systems could run in parallel, but how would anything useful come from that in the short term? What selective of advantage of 3-base coding could be strong enough to overcome any disruption?

Has anyone developed a coherent model of what intermediate stages might look like?

$\endgroup$
5
$\begingroup$

It is not suggesting a 2-base->3-base code in the way you are thinking, but of a non-coding, two-coding triplet pattern occurring first.

This means you would have 16 different coding sequences with 4 possible spacing bases in between.

Later, the spacing bases could become used as part of the code.

Does that make more sense? Instead of AA,CG becoming AAT,CGT; AAX,CGX becomes AAT,CGT etc.

Its also likely that between 2 and 3 base codes a 2 base pyrimidine/purine system was used. Today the third base can often be switched for its pyrimidine/purine pair without changing the resulting amino acid.

$\endgroup$
  • 1
    $\begingroup$ Yes, that does make more sense. Thanks, Nick. Do you have a source for this, though? $\endgroup$ – Jack Aidley Jan 29 '13 at 18:01
1
$\begingroup$

Erives' paper is interesting:

A model of proto-anti-codon RNA enzymes requiring L-amino acid homochirality.

$\endgroup$
  • 1
    $\begingroup$ Why is it interesting? Try to include a summary of anything you're linking to in your own words. $\endgroup$ – Rory M Jan 30 '13 at 16:36

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.