I was reading up on causative factors of leukemia on medicinenet and I came across the following statement:
...an exchange between chromosomes 9 and 22 leads to what is known as the Philadelphia chromosome.
What is the mechanism behind this? Is it purely mechanical? Would the locations on both chromosome’s be equidistance from the end (for lack of biology vocabulary.) In other words, would each segment involved in the swap have to be similarly sized?