I am doing research on Stochastic Cooperative Game Theory (a subfield in mathematics), which I will henceforth call SCGT for convenience. In this theory, entities can work together to receive a bigger combined payoff than they would otherwise receive if they had not worked together. In the stochastic version of cooperative game theory, the payoffs are not deterministic, but follow a probability distribution.
It seemed to me I could apply this theory to drug synergy. If there is drug synergy, there is a (high) chance that two medicines combined are better at healing a patient than just multiplying the dosage of either medicine by $2$. With SCGT, I could determine how much each medicine contributes to the healing of the patient, if some information is known about the drug-response curves. This in turn could tell us something about how much the manufacturers of each drug receive to be paid (in theory).
However, I am not quite well-acquainted with the literature on drug synergy. Furthermore, I can't access many articles on the topic without paying a lot (as I'm with the mathematics department at the university, I can't view articles on biology for free).
So my questions are:
- Do you know any open-source articles in which it is shown that two drugs work in synergy according to the Bliss Independence model?
- Do you know any open-source articles in which it is shown that three or more drugs work in synergy according to the Bliss Independence model?
The same questions apply to the Loewe additivity framework.