I do remember that I have read (or heard) somewhere that as a human is older, the whole cell vaccine (and high antigen dose one) has more and more adverse effects.
As it is consistent with the target age group mentioned in the leaflets attached to the vaccines:
- whole-cell DTP vaccine (Instytut Biotechnologii Surowic i Szczepionek BIOMED S.A.) is suitable "for children not older then 3 years",
- high antigen doseInfanrix-DTPa (GlaxoSmithKline Biologicals S.A.) "shall not be used for children older than 7 years",
- low antigen dose Boostrix (GlaxoSmithKline Biologicals S.A.) is "suitable for a person older than 4 years",
I suspect it is true. Unfortunately I lack a reliable source to both confirm that and read more about the effects. Can anyone provide a reference.
As there is a strain of pertussis "resistant" to acellular vaccine, IMHO it would make much more sense to use whole-cell vaccine for adults too.