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Assume we're talking about lymphocyte migration. I think rolling is referring to part of the process of infection by chemotaxis but beyond that...

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Weak adhesion and strong adhesion depends on the upregulation of selectins and the site where it is formed.In the normal case, immune cells like neutrophils undergo rolling motion due to the presence of L selectin in them which specifically binds carbohydrate parts of certain proteins found in endothelial cells of the blood vessel.But at the site of inflammation where these immune cells have to emigrate into tissue sites, a strong adhesion is needed rather than rolling thus endothelial cells express selecting which now trap immune cells.They upregulate P and E selectins along with integrins to trap more immune cells.

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  • $\begingroup$ Are there specific books or resources in which I can find out more about this, which you might recommend? $\endgroup$ – Daniel O'Hearn Mar 18 '18 at 15:47
  • $\begingroup$ Alberts Molecular Biology of cell and Immunobiology janeway.. $\endgroup$ – Sarannya E Mar 18 '18 at 15:56

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